EFFECTS OF HOMOCYSTEINE ON eNOS AND DDAH GENE EXPRESSION LEVELS IN PRIMARY HUMAN UMBILICAL ENDOTHELIAL CELL CULTURE


AKKİPRİK M. , Cevik D., Ozer A., Emerk K.

MARMARA MEDICAL JOURNAL, vol.20, no.3, pp.144-149, 2007 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2007
  • Title of Journal : MARMARA MEDICAL JOURNAL
  • Page Numbers: pp.144-149

Abstract

Aim: Elevated plasma homocysteine levels are independent risk factors for myocardial infarction, stroke and peripheral vascular disease. The aim of this study was to investigate effects of homocysteine on nitric oxide (NO) synthesis, bioavailability and degradation by analysis gene expression levels of endothelial nitric oxide synthase (eNOS) and dimethylarginine dimethylaminohydrolase (DDAH) and also NO levels in endothelial cell line.