Collagen ultrastructure and TGF-beta 1 expression preserved with aminoguanidine during wound healing in diabetic rats

Yavuz D. , Tugtepe H., Cetinel S., Uyar S., Kaya H., Haklar G. , ...Daha Fazla

ENDOCRINE RESEARCH, cilt.31, sa.3, ss.229-243, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Konu: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/07435800500373140
  • Sayfa Sayıları: ss.229-243


Advanced glycoxidation end products have been implicated in delayed diabetic wound healing. In this study, we evaluated the effects of aminoguanidine, which is an advanced glycation and nitric oxide ( NO) synthase inhibitor, on extracellular matrix protein expression, collagen configuration, and nitrite/nitrate levels in wounds of diabetic rats.