Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine


Odabasi Z., Karaalp A. , Cermik H., Mohr J., Tigen E. T. , Koc M. , ...More

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.53, no.7, pp.3100-3102, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1128/aac.00001-09
  • Title of Journal : ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  • Page Numbers: pp.3100-3102

Abstract

The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).