Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells

Moon H., Batirel S., Mantzoros C. S.

METABOLISM-CLINICAL AND EXPERIMENTAL, cilt.63, sa.11, ss.1447-1454, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.metabol.2014.07.009
  • Dergi Adı: METABOLISM-CLINICAL AND EXPERIMENTAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1447-1454
  • Anahtar Kelimeler: Alpha Linolenic acid, Oleic acid, Esophageal cancer, Malignant potential, AMPK/S6 axis, ACTIVATED PROTEIN-KINASE, BREAST-CANCER, FATTY-ACIDS, SIGNALING PATHWAY, CARCINOMA, GROWTH, PROSTATE, DISEASE, LIPIDS, RISK
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective. Both oleic acid (OA) and alpha-linolenic acid (ALA) have been proposed to down-regulate cell proliferation of prostate, breast, and bladder cancer cells. However, direct evidence that OA and/or ALA suppresses to the development of esophageal cancer has not been studied. Also, no previous studies have evaluated how OA and/or ALA regulates malignant potential (cell proliferation, migration, colony formation and adhesion) and intracellular signaling pathways, and whether their effects might be synergistic and/or additive in esophageal cancer cells has not yet been elucidated.