Akademik Veri Yönetim Sistemi
Journal of Oncological Science, cilt.11, sa.2, ss.104-111, 2025 (Scopus)
Objective: Malignant peritoneal mesothelioma (MPM) is a rare and aggressive malignancy with limited survival, often associated with asbestos exposure. This study aimed to analyze the demographic and clinical characteristics of MPM patients, determine factors influencing survival, and evaluate the effectiveness of current treatment modalities. Material and Methods: A retrospective, multicenter analysis was conducted on 40 patients diagnosed with MPM between 2009 and 2022. Demographic, histological, and treatment-related data were collected. Survival outcomes, including progression-free survival (PFS) and overall survival (OS), were analyzed using Kaplan-Meier curves and Cox regression models. Results: The median age of the cohort was 59, and 70% were male. Epithelioid histology was the most common subtype (77.5%) and was associated with significantly better OS (median: 49 months) compared to non-epithelioid subtypes (median: 5 months, p<0.001). Patients who underwent cytoreductive surgery (CRS) demonstrated significantly improved OS. Hyperthermic intraperitoneal chemotherapy (HIPEC) was associated with prolonged PFS (26.18 vs. 6.63 months, p=0.013), though its impact on OS was not statistically significant in multivariate analysis. Conclusion: Histological subtype and treatment strategy significantly influence MPM outcomes. Epithelioid histology correlates with better survival, while aggressive interventions such as CRS and HIPEC offer survival advantages in selected patients. Multidisciplinary approaches and individualized therapeutic strategies are critical to improving prognosis in MPM.