Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Sumer Edition, Bucuresti, Romanya, 25 - 27 Haziran 2025, ss.74-75, (Özet Bildiri)
Migraine is a type of headache that is felt with severe pain on one side of the head as a result of abnormal brain activity that temporarily affects nerve signals and narrowing of blood vessels. It restricts the individual’s social activities and business life. Various drug use methods such as oral, systemic and intranasal routes are being investigated for migraine treatment. Among these, intranasal drug use is significantly advantageous for rapid and accurate release of the drug. Besides, systemic exposure and potential peripheral side effects of the drug are reduced. New drug delivery systems such as liposomes, microemulsions, nanoparticles, and in situ gels have been reported to enhance the intranasal release of drugs. However, these passive modes of administration are challenged by the rapid clearance of nasal cilia and the barrier function of the nasal mucosa during drug delivery. Because of that new approaches are needed to increase drug absorption. Preferred by this need, the use of microneedles is envisaged to improve the release of drugs into the brain by overcoming possible obstacles during drug absorption through the nose. In this research, microneedles were produced by a DLP 3D printer. Gelatin methacryloyl (GelMA) was used as a matrix material to obtain microneedles (MNs), and salicylic acid (SA) was loaded to investigate the release behaviour of the SA from the needles. Morphological analysis of microneedles was carried out using a scanning electron microscope (SEM). Fourier transform infrared (FTIR) spectrometer was used to investigate their molecular structures. In vitro cytotoxicity analysis of the microneedles (MNs) was performed using mesenchymal stem cells, and they were found to be biocompatible. Based on the results of the analyses, the MNs were determined to be suitable for development for intranasal drug delivery.