Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Sumer Edition, Bucuresti, Romanya, 25 - 27 Haziran 2025, ss.70-71, (Özet Bildiri)
Skin diseases, such as thermal burns and diabetic leg ulcers, can damage the dermal and epidermal layers, depending on injury depth and extent. Infection poses a major risk in these wounds. Wound dressings are essential in treating injured skin, as they shield open wounds from infection-causing external factors and mechanical irritation. They help retain moisture, preventing scab formation, which can reduce scarring. These functions not only accelerate tissue regeneration but also alleviate pain and discomfort. Beyond these basic features, some wound dressings include antimicrobial agents, growth factors, or other healing-supportive substances that can be released in a controlled manner. This enables wound treatment tailored to the type of wound and patient needs. Polyurethane films are preferred for wound dressings due to several advantages. Their flexible and thin structure adapts to body movements, making them ideal for wounds on joint areas. They are tear-resistant and protect against physical impacts. Being semi-permeable, they allow oxygen and water vapor to pass while blocking bacteria. Polyurethane’s biocompatibility reduces the risk of skin irritation, and some types are biodegradable, aiding in waste management. Their transparency allows for observation of the healing process without removal. In this study, films with different polyurethane ratios were produced via precise casting. Their mechanical, chemical, biological, and morphological properties were characterized, and in vitro biocompatibility tests were conducted. The results indicate a product with potential therapeutic benefits. This study is anticipated to lay a foundation for further research on incorporating antibacterial agents, drugs, growth factors, vitamins, peptides, and collagen into polyurethane film structures.