Effects of Ozone on Injury after Gamma Knife Radiosurgery.

Emon S. T., Unal S., Arslanhan A., Bozkurt S., Meric Z. C., Ziyal I.

World neurosurgery, cilt.149, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 149
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.wneu.2021.01.061
  • Dergi Adı: World neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Index Islamicus, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Gamma knife radiosurgery, Ozone, Radioprotective, Rat, NORMAL RAT-BRAIN, ENDOTHELIAL GROWTH-FACTOR, RADIATION NECROSIS, EXPRESSION, STRESS, DAMAGE
  • Marmara Üniversitesi Adresli: Evet

Özet

BACKGROUND: At present, gamma knife radiosurgery plays an important role in neurosurgical procedures. Gamma knife radiosurgery has been used to treat many types of brain tumors and as a functional intervention. However, gamma knife treatment has a devastating effect on the normal brain parenchyma surrounding the target point. It causes increased vascular permeability, vasodilation, and swelling in endothelial cells. Ozone has antioxidant, antiapoptotic, and anti-inflammatory effects in the body. Thus, we evaluated the radioprotective effects of ozone in rats undergoing gamma knife radiation.