In vivo antioxidant and anti-inflammatory effects of Myrtus communis against ionizing radiation-induced gastrointestinal injury: TROD-GROG-002 study
NORTHERN CLINICS OF ISTANBUL = ISTANBUL KUZEY KLINIKLERI, cilt.12, sa.6, ss.730-738, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 6
- Basım Tarihi: 2025
- Doi Numarası: 10.14744/nci.2025.89588
- Dergi Adı: NORTHERN CLINICS OF ISTANBUL = ISTANBUL KUZEY KLINIKLERI
- Derginin Tarandığı İndeksler: Scopus, Emerging Sources Citation Index (ESCI), Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.730-738
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Marmara Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to investigate the in vivo radioprotective effects of Myrtus
communis (MC) on the gastrointestinal system.
Methods: A total of 30 female rats were divided into four groups: i) Control; ii) irradiation
(IR) only; iii) MC-pretreated; and iv) MC-treated. The rats received oral MC extract (100
mg/kg/day) for 4 days before exposure to 10 Gy IR or continued until sacrifice. On the fourth
day of IR exposure, the rats were sacrificed, and histopathological and biochemical analyses
were performed on the ileum, pancreas, and liver tissues.
Results: Malondialdehyde and myeloperoxidase levels decreased in both MC-treated groups,
while glutathione levels and Na+-K+-ATPase activity increased (P<0.01), with significant
histopathological improvements compared with the IR-only group.
Conclusion: The results of this study demonstrate that MC significantly decreases ionizing
radiation-induced oxidative and inflammatory damage in the gastrointestinal systems of rats.
Therefore, it may be regarded as a new candidate with radioprotective potential for future
clinical application.