Amygdala kindling in the WAG/Rij rat model of absence epilepsy

Aker R., Yananli H. R., Gurbanova A., Ozkaynakci A., Ates N., van Luijtelaar G., ...Daha Fazla

EPILEPSIA, cilt.47, sa.1, ss.33-40, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1528-1167.2006.00367.x
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.33-40
  • Anahtar Kelimeler: absence epilepsy rats, spike-and-wave discharge, generalized epilepsy, partial epilepsy, convulsion, GAERS, SPIKE-WAVE DISCHARGES, ELECTRICAL-STIMULATION, SEIZURES, COEXISTENCE, EXCITATION, THALAMUS, NEURONS, STRAIN, CA1
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose: The kindling model in rats with genetic absence epilepsy is suitable for studying mechanisms involved in the propagation and generalization of seizure activity in the convulsive and nonconvulsive components of epilepsy. In the present study, we compared the amygdala kindling rate and afterdischarge characteristics of the nonepileptic Wistar control rat with a well-validated model of absence epilepsy, the WAG/Rij rat, and demonstrated the effect of amygdala kindling on spike-and-wave discharges (SWDs) in the WAG/Rij group.