Association between occurrence of ossicular chain defect and osteoprotegerin gene expression in patients with chronic otitis media


Keskin S., Tatlipinar A., ATA P. , Uzun S., Kinal M. E. , Erkal B.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, cilt.276, sa.5, ss.1321-1325, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 276 Konu: 5
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s00405-019-05366-z
  • Dergi Adı: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Sayfa Sayıları: ss.1321-1325

Özet

Objective Chronic otitis media (COM) is an important debilitating public problem causing hearing loss due to irreversible resorption of the ossicular chain. Activation of osteoprotegerin (OPG) during an acute attack of COM prevents bone resorption. The aim of the study was to investigate the role of OPG gene expression level on ossicular chain resorption in chronic otitis media.