Association between occurrence of ossicular chain defect and osteoprotegerin gene expression in patients with chronic otitis media


Keskin S., Tatlipinar A., ATA P. , Uzun S., Kinal M. E. , Erkal B.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, vol.276, no.5, pp.1321-1325, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 276 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1007/s00405-019-05366-z
  • Title of Journal : EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Page Numbers: pp.1321-1325

Abstract

Objective Chronic otitis media (COM) is an important debilitating public problem causing hearing loss due to irreversible resorption of the ossicular chain. Activation of osteoprotegerin (OPG) during an acute attack of COM prevents bone resorption. The aim of the study was to investigate the role of OPG gene expression level on ossicular chain resorption in chronic otitis media.