Neuroprotective effects of mildronate in a rat model of traumatic brain injury


Demir D., Kuru Bektaşoğlu P., KOYUNCUOĞLU T. , Kandemir C., AKAKIN D. , YÜKSEL M. , ...More

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.50, no.10, pp.1586-1592, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.1016/j.injury.2019.08.036
  • Title of Journal : INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Page Numbers: pp.1586-1592

Abstract

Objective: Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic diseases via anti-inflammatory, antioxidant, and neuroprotective mechanisms. This study aimed to investigate possible antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective effects of mildronate in a rat model of TBI.