Neuroprotective effects of mildronate in a rat model of traumatic brain injury


Demir D., Kuru Bektaşoğlu P., KOYUNCUOĞLU T. , Kandemir C., AKAKIN D. , YÜKSEL M. , ...Daha Fazla

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, cilt.50, sa.10, ss.1586-1592, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Konu: 10
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.injury.2019.08.036
  • Dergi Adı: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Sayfa Sayıları: ss.1586-1592

Özet

Objective: Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic diseases via anti-inflammatory, antioxidant, and neuroprotective mechanisms. This study aimed to investigate possible antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective effects of mildronate in a rat model of TBI.