CALCIUM-CHANNEL BLOCKERS PREVENT STRESS-INDUCED ULCERS IN RATS


YEGEN B. , ALICAN I., YALCIN A. S. , OKTAY S.

AGENTS AND ACTIONS, vol.35, pp.130-134, 1992 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35
  • Publication Date: 1992
  • Doi Number: 10.1007/bf01990962
  • Title of Journal : AGENTS AND ACTIONS
  • Page Numbers: pp.130-134

Abstract

Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.