CALCIUM-CHANNEL BLOCKERS PREVENT STRESS-INDUCED ULCERS IN RATS


YEGEN B. , ALICAN I., YALCIN A. S. , OKTAY S.

AGENTS AND ACTIONS, cilt.35, ss.130-134, 1992 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 35
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1007/bf01990962
  • Dergi Adı: AGENTS AND ACTIONS
  • Sayfa Sayıları: ss.130-134

Özet

Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.