Oxygen-Generating Photocrosslinkable Hydrogel


Alemdar N.

CELL-BASED MICROARRAYS: METHODS AND PROTOCOLS, cilt.1771, ss.241-250, 2018 (Diğer Kurumların Hakemli Dergileri) identifier identifier

  • Cilt numarası: 1771
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/978-1-4939-7792-5_19
  • Dergi Adı: CELL-BASED MICROARRAYS: METHODS AND PROTOCOLS
  • Sayfa Sayıları: ss.241-250

Özet

Providing sufficient amount of oxygen to the cells is a critical issue since the lack of adequate oxygen leads to cell death and tissue necrosis. Therefore, there is a vital need to design and fabricate oxygen-generating biomaterials to mitigate hypoxia-induced cell death in engineered tissues. Here, we report the fabrication of an oxygen-generating hydrogel by incorporating calcium peroxide (CPO) into the methacrylated gelatin (GelMA) structure using photocrosslinking process. A sustainable release of oxygen could be provided from CPO-GelMA hydrogel over a period of 5 days under hypoxic conditions (1% O-2).