Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population

Isik N., ARMAN A., Canturk I. A., Gurkan A., Candan F., Aktan S., ...Daha Fazla

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.123, sa.10, ss.711-718, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 123 Sayı: 10
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/00207454.2013.795563
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.711-718
  • Anahtar Kelimeler: demyelinating disease, interleukin-1, cytokine, genotype distribution, RECEPTOR ANTAGONIST IL-1RA, DISEASE SEVERITY, RHEUMATOID-ARTHRITIS, ADHESION MOLECULE, IL-1-BETA, SUSCEPTIBILITY, CELLS, RISK, RELEVANCE, INTRON-2
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin (IL)-1 family are candidate genes for MS susceptibility. Objective: To determine the relationship between IL-1 gene family and MS in the Turkish population. Methods: A total of 409 MS patients and 256 healthy controls were included in the study. IL-1A -889 (rs1800587), IL-1 RN variable number tandom repeat (VNTR), IL-1B -511 (rs 16944) and IL-1B +3953 (rs 1143634) polymorphisms were investigated from the genomic DNA, obtained via blood samples. Results: No association was found between IL-1A and IL-1RN polymorphisms and susceptibility to MS. However, we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in MS patients compared to controls. In addition, there was a significant association between IL-1B -511 (1/2) genotype and early onset MS (EOMS) (p = 0.0001). Conclusions: Individuals with the 2/2 genotype of IL-1B -511 have significantly decreased incidence of MS, suggesting a protective role for this genotype in the Turkish population. Additionally, IL-1B -511(1/2) genotype was determined as a possible risk factor for EOMS.