Th17 Differentiation in Hyper-IgE Syndrome; IL-17 Secretion and ROR gamma t Expression

AKKOÇ, TUNÇ; Ogulur, İSMAİL; Tevetoglu, Ayzer; Izgi, Aysegul; Hatirnaz-Ng, Ozden; Yin-Ng, Yuk; Safa, Baris; Aydiner-Karakoc, Elif

doi:10.5455/musbed.20130102082754

Th17 Differentiation in Hyper-IgE Syndrome; IL-17 Secretion and ROR gamma t Expression

AKKOÇ T., Ogulur I., Tevetoglu A., Izgi A., Hatirnaz-Ng O., Yin-Ng Y., ...Daha Fazla

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.3, sa.5, 2013 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 3 Sayı: 5
Basım Tarihi: 2013
Doi Numarası: 10.5455/musbed.20130102082754
Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
Anahtar Kelimeler: Th17, interleukin 17 (IL-17), RAR-related orphan receptor gamma t (ROR-gamma t), Hyper-IgE syndrome (HIES)
Marmara Üniversitesi Adresli: Evet

Özet

Objective: Hyper-IgE syndrome (HIES) is characterized by susceptibility to infection and low number of Th17 cells. Th17 is believed to be critical in the clearance of fungal and extracellular bacterial infections. Present study investigates the differentiation of Th17 cells by evaluation of interleukin 17 (IL-17) secretion and RAR-related orphan receptor gamma t (ROR gamma t) expression in HIES compared with healthy subjects.