Protein Pool Maintenance During Oxidative Stress

Catalgol B., Grune T.

CURRENT PHARMACEUTICAL DESIGN, cilt.15, sa.26, ss.3043-3051, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 26
  • Basım Tarihi: 2009
  • Doi Numarası: 10.2174/138161209789058129
  • Dergi Adı: CURRENT PHARMACEUTICAL DESIGN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3043-3051
  • Anahtar Kelimeler: Reactive species, oxidative stress, protein oxidation, proteolysis, proteasome, PROTEASOME PROTEOLYTIC PATHWAY, OXIDIZED PROTEINS, MAMMALIAN-CELLS, OXYGEN RADICALS, 20S PROTEASOME, 26S PROTEASOME, IN-VITRO, MITOCHONDRIAL-MEMBRANE, SELECTIVE DEGRADATION, METHIONINE RESIDUES
  • Marmara Üniversitesi Adresli: Hayır

Özet

The production of reactive species causes oxidative modifications of proteins accompanied by a loss of protein function. By protein oxidation all cellular compartments and any amino acid are effected. This might result in a defect of cellular homeostasis. Therefore, the degradation of non-functional, oxidized proteins is an essential function of the proteolytic branch of the antioxidant defense machinery. The major proteolytic system responsible for the removal of oxidized proteins is the proteasomal system. Whereas moderately oxidized proteins are more sensitive to proteolytic attack, severely oxidized ones are often poor substrates and might, however, inhibit the proteasome.