Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats


Gedik N., Kabasakal L., Sehirli O., Ercan F., Sirvanci S., Keyer-Uysal M., ...Daha Fazla

LIFE SCIENCES, cilt.76, sa.22, ss.2593-2606, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 22
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.lfs.2004.11.021
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2593-2606
  • Anahtar Kelimeler: garlic, bile duct ligation, fibrosis, oxidative damage, VASCULAR ENDOTHELIAL-CELLS, HEPATIC STELLATE CELLS, BILE-DUCT LIGATION, MYELOPEROXIDASE ACTIVITY, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, S-ALLYLCYSTEINE, RENAL DAMAGE, STRESS, INJURY
  • Marmara Üniversitesi Adresli: Evet

Özet

The aim of this study was to assess the antioxidant and antifibrotic effects of chronic administration of aqueous garlic extract on liver fibrosis induced by biliary obstruction in rats. Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL).