Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats

Gedik, N; Kabasakal, LEVENT; Sehirli, O; Ercan, FERİHA; Sirvanci, SERAP; Keyer-Uysal, M; Sener, GÖKSEL

doi:10.1016/j.lfs.2004.11.021

Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats

Atıf İçin Kopyala

Gedik N., Kabasakal L., Sehirli O., Ercan F., Sirvanci S., Keyer-Uysal M., ...Daha Fazla

LIFE SCIENCES, cilt.76, sa.22, ss.2593-2606, 2005 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 76 Sayı: 22
Basım Tarihi: 2005
Doi Numarası: 10.1016/j.lfs.2004.11.021
Dergi Adı: LIFE SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2593-2606
Anahtar Kelimeler: garlic, bile duct ligation, fibrosis, oxidative damage, VASCULAR ENDOTHELIAL-CELLS, HEPATIC STELLATE CELLS, BILE-DUCT LIGATION, MYELOPEROXIDASE ACTIVITY, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, S-ALLYLCYSTEINE, RENAL DAMAGE, STRESS, INJURY
Marmara Üniversitesi Adresli: Evet

Özet

The aim of this study was to assess the antioxidant and antifibrotic effects of chronic administration of aqueous garlic extract on liver fibrosis induced by biliary obstruction in rats. Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL).