The Determination of the Stability Constant of Finasteride Complexes with Various Metals by Potentiometric and Spectrophotometric Methods

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Cücü A., Arslan E., Karaderi S.

MARMARA PHARMACEUTICAL JOURNAL, cilt.20, ss.408-414, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2016
  • Doi Numarası: 10.12991/mpj.34400
  • Dergi Adı: MARMARA PHARMACEUTICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.408-414
  • Marmara Üniversitesi Adresli: Evet

Özet

In this study, the stability constants of the cobalt(II), zinc(II), cadmium(II) and copper(II) complexes of finasteride were determined potentiometrically by using Irving-Rossotti and Calvin-Bjerrum methods and supported by spectrophotometric way [1-3]. The evaluated protonation constant of finasteride was found as logK=2,21. Potentiometrically the logarithms of the stability constants of the finasteride-metal complexes were found by Calvin-Bjerrum and Irving-Rossotti methods: for cobalt(II) complex logK=3,01; for zinc(II) complex logK=2,82; for cadmium(II) complex logK=3,04 and for copper complex logK=2,85 at 25 degrees C (I=0,10). Conditional formation constants of the complexes were calculated and pH ranges of the complexation were found.