THYROID DYSGENESIS AND THE DYSPLASIA HYPOTHESIS IN TUBEROUS SCLEROSIS


BEREKET A. , WILSON T.

AMERICAN JOURNAL OF MEDICAL GENETICS, cilt.47, sa.3, ss.417-419, 1993 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Konu: 3
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1002/ajmg.1320470324
  • Dergi Adı: AMERICAN JOURNAL OF MEDICAL GENETICS
  • Sayfa Sayıları: ss.417-419

Özet

Thyroid dysfunction is rare in tuberous sclerosis, although papillary adenomas (hamartomas) of the thyroid gland have been reported in a few autopsy cases. We describe a child with tuberous sclerosis and primary congenital hypothyroidism secondary to a dysgenetic thyroid gland. To our knowledge, this association has not been reported previously. Although the association of these two disorders in one patient may be merely coincidence, we speculate that the dysgenetic thyroid gland in this patient may represent a ''hamartia'' as a consequence of the tuberous sclerosis gene. (C) 1993 Wiley-Liss, Inc.