Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fatty liver disease

Fotbolcu H., Yakar T., Duman D., Karaahmet T., Tigen K., Cevik C., ...More

Cardiology Journal, vol.17, no.5, pp.457-463, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2010
  • Journal Name: Cardiology Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.457-463
  • Keywords: left ventricular function, non-alcoholic fatty liver disease, echocardiography, FASTING PLASMA-GLUCOSE, INSULIN-RESISTANCE, TISSUE DOPPLER, METABOLIC SYNDROME, NATURAL-HISTORY, STEATOHEPATITIS, MASS, ASSOCIATION, OBESITY, HYPERTENSION
  • Marmara University Affiliated: No

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome. We investigated the diastolic and systolic functional parameters of patients with NAFLD and the impact of metabolic syndrome on these parameters.Methods: Thirty-five non-diabetic, normotensive NAFLD patients, and 30 controls, were included in this study. Each patient underwent transthoracic conventional and tissue Doppler echocardiography (TDI) for the assessment of left ventricular (LV) diastolic and systolic func- tion. Study patients were also evaluated with 24-hour ambulatory blood pressure monitoring. Results: NAFLD patients had higher blood pressures, increased body mass indices, and more insulin resistance than controls. TDI early diastolic velocity (E' on TDI) values were lower in NAFLD patients than the controls (11.1 ± 2.1 vs 15.3 ± 2.7; p < 0.001). TDI systolic velocity (S' on TDI) values were lower in NAFLD patients than the controls (9.34 ± 1.79 vs 10.6 ± 1.52; p = 0.004). E' on TDI and S' on TDI values were moderately correlated with night-systolic blood pressure, night-diastolic blood pressure, and night-mean blood pressure in NAFLD patients. Conclusions: Patients with NAFLD have impaired LV systolic and diastolic function even in the absence of morbid obesity, hypertension, or diabetes. © 2010 Via Medica.