Akademik Veri Yönetim Sistemi
“Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2022 – Winter Edition, Bucuresti, Romanya, 24 - 26 Kasım 2022, ss.53-54
Skin is an important part of integumentary system and the excretory system, which can be injured and
healed by the own body cells by having complex biological processes which generally needs 4 to 6 weeks
according to injury type which differ according to etiology into surgical, penetrating, blunt, burn wounds,
although,the depth of wound, severity, skin integrity and the degree of contamination plays a role in duration
of wound healing. On the other hand other factors effect, some of this factors are local facors like
oxygenation, infection, foreign body, venous and sufficiency, some of them are systemic factors like Age,
gender, sex hormones, stress, ischemia, diseases (diabetes, uremia, obesity), medications (anti-inflammatory
drugs, chemotherapy), Alcoholism, smoking, and Nutrition. For faster healing processes, 3D printed
scaffolds were fabricated and coated with microparticles on its surface. In this study, PLA/PMSQ 3D printed
scaffolds were fabricated and coated with vitamin E microparticles. Ethyl cellulose (EC) was mixed with
vitamin E and used to load the vitamin E on the scaffolds by using electrospray device. PLA was used due
to its desired properties of being biocompatible and providing controlled release of functional drugs and
supplements. PMSQ was mixed with it due to its high hydrophobicity and prevents agglomeration and
maintains free-flowing characteristics in loose-powder products. EC was used as barrier to deliver vitamin
E microparticles and assist releasing of vitamin E process on the skin due to its hydrophobicity, lipophilicity
and non-toxicity properties. Vitamin E was used because of its occlusive effect that provides penetration of
the vitamin on the skin, and its chemical stability. The mechanical, thermal, chemical properties and
morphological analysis of the vitamin E coated PLA/PMSQ scaffolds were examined. The drug release
behaviour was tested in vitro and the biocompatibility test was done using MTT assay with fibroblast cell
line.