Efficacy of interferon alpha-2b and lamivudine combination treatment in comparison to interferon alpha-2b alone in chronic delta hepatitis: A randomized trial


Canbakan B., Senturk H., Tabak F., Akdogan M., Tahan V., Mert A., et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.21, ss.657-663, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 21 Konu: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1440-1746.2006.04082.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Sayfa Sayısı: ss.657-663

Özet

Background and Aim: Delta hepatitis is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Patients benefit from high doses and prolonged courses of interferon (IFN) therapy; however, lamivudine as a single agent has been disappointing. Data relating to the efficacy of IFN and lamivudine in combination is limited. The aim of this study was to test the efficacy of IFN-alpha 2b and lamivudine combination treatment in comparison to IFN-alpha 2b alone in patients with chronic delta hepatitis.