New alternative agents in essential tremor therapy: double-blind placebo-controlled study of alprazolam and acetazolamide

Gunal D., Afsar N. E. Y., Bekiroglu N., Aktan S.

NEUROLOGICAL SCIENCES, cilt.21, sa.5, ss.315-317, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 5
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1007/s100720070069
  • Dergi Adı: NEUROLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.315-317
  • Anahtar Kelimeler: essential tremor therapy, alprazolam, acetazolamide, elderly, PRIMIDONE, EFFICACY, TRIAL
  • Marmara Üniversitesi Adresli: Evet

Özet

Propranolol and primidone are widely used, effective agents in essential tremor although they are not tolerated by all patients. In the present study, the effectiveness of alprazolam, a triazole analog of benzodiazapine class, and acetazolamide, a carbonic anhydrase inhibitor, were investigated as symptomatic treatments for essential tremor. We studied 22 patients with essential tremor in a double-blind, cross-over, placebo-controlled design. The patients received in random order alprazolam, acetazolamide, primidone and placebo for four weeks, each separated by a two-week washout period. The study demonstrated that alprazolam was superior to placebo and equipotent to primidone, whereas there was no statistically significant difference between acetazolamide and placebo. The mean effective daily dose of alprazolam was 0.75 mg and there was not any troublesome side effect reported by the patients on alprazolam. Alprazolam can be used as an alternative agent in elderly essential tremor patients who can not tolerate primidone or propranolol.