Acquired progressive lymphangioma: Case report with partial response to imiquimod 5% cream

SALMAN A. , SARAÇ G. , Kuru B. C. , Cinel L. , YÜCELTEN A. D. , Ergun T.

PEDIATRIC DERMATOLOGY, vol.34, no.6, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1111/pde.13283
  • Title of Journal : PEDIATRIC DERMATOLOGY
  • Keywords: dermatopathology, hemangiomas, vascular tumors, topical therapy


Acquired progressive lymphangioma (APL), or benign lymphangioendothelioma, is an unusual entity derived from vascular structures. Clinically and histopathologically it may resemble Kaposi's sarcoma and well-differentiated angiosarcoma, causing a diagnostic problem. We report an individual with APL initially diagnosed with Kaposi's sarcoma who underwent unnecessary laboratory testing. Imiquimod 5% cream stopped the progression of the lesion. Awareness of this rare entity may prevent patients from undergoing excessive testing. Imiquimod may be used as a safe, effective treatment option.