The effect of glutathione preconditioning on heme oxygenase-1 system established by whey protein feeding on hepatocellular injury in a rat hepatic normothermic i/r injury model

Manukyan M. N., Yavuz Y., Erbarut I., Ogunc A. V., Ataizi-Celikel Ç., Yalcin A. S., ...Daha Fazla

TURKISH JOURNAL OF SURGERY, cilt.24, sa.3, ss.137-144, 2008 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2008
  • Dergi Adı: TURKISH JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.137-144
  • Anahtar Kelimeler: Liver, ischemia/reperfusion, whey, glutathione, heme oxygenase-1
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose: Oxygen radicals which are produced during reperfusion phase play a central role for hepatocellular damage during ischemia/reperfusion (I/R) injury. Antioxidant strategies appear a promising approach to prevent I/R injury. In the present study, the effect of glutathione (GSH) preconditioning established by whey protein feeding on hepatocellular injury markers was assessed in a rat hepatic normothermic I/R injury model. The interaction between intracellular GSH content and heme oxygenase-1 (HO-1) enzyme expression was also determined in order to understand the level of upgrading of HO-1 system in a high GSH content environment after preconditioning.