Akademik Veri Yönetim Sistemi
Journal of the Hellenic Veterinary Medical Society, cilt.76, sa.1, ss.8597-8606, 2025 (SCI-Expanded)
The study was carried out to examine the safety and potential activities of myo-inositol as an antioxidant, preservative, hygiene enhancer, and antiviral feed additive in pet nutrition. For this purpose, the vitamin C equivalent antioxidant capacity (VCEAC of myo-inositol was measured by MTT assay. The cytotoxicity (CC50) of myo-inositol was experimented on mammalian kidney and liver cell lines. The virucidal and antiviral activities of myo-inositol were determined against murine norovirus-1 (MNV-1). One milligram of myo-inositol equals the antioxidant capacity of 0.454 mg of vitamin C. The CC50 was determined between 280 and 966 mg/ml for kidney and liver cell cultures. Myo-inositol exhibited dose-dependently virucidal activity against MNV-1 as a surrogate for pet caliciviruses. In three different antiviral experiments, 50% inhibition concentrations were determined as 0.054, 0.084, and 0.047 mg/ml. This in vitro study presents that myo-inositol might be a potential candidate as an antioxidant, preservative, and hygiene enhancer feed additive against oxidative deterioration and microbial contamination in feed production technology for ensuring feed safety and promoting pet health.