Research Information System
Journal of Research in Pharmacy, vol.30, no.2, pp.730-742, 2026 (ESCI, Scopus, TRDizin)
This prospective randomized controlled study aimed to assess medication adherence, diabetes-related knowledge, associated treatment outcomes, and quality of life in patients with type 2 diabetes mellitus (T2DM). The study was conducted in a training and research hospital in Istanbul with a one-year follow-up. Medication adherence, disease knowledge, and quality of life were measured using the Morisky–Green–Levine (MGL) scale, an 18-item self-structured scale, and the WHOQOL-BREF questionnaire, respectively. The main targets were a reduction in HbA1c levels, improvement in quality of life, knowledge levels, and medication adherence. The study included 114 patients. Of them, 57 patients were in the intervention group (IG) and received pharmaceutical care services. The mean duration of diabetes among the patients was 14.6±7.3 years. A total of 89.4% of patients had low levels of education, and half of the participants were female. Adherence and knowledge levels improved significantly by the end of the study (p=0.021 and p=0.047, respectively) in the IG compared to the CG. A statistically significant difference was observed only in the physical dimension of the WHOQOL-BREF questionnaire (p=0.004) in the IG compared to the CG. HbA1c levels decreased by 1.36%, and the reduction in fasting blood glucose was also statistically significant (p<0.001) in the IG. Additionally, the clinical pharmacist made 86 recommendations regarding drug-related problems to the specialist doctor, 81.39% of which were accepted. By the end of the study, 31.81% of patients in the IG achieved the treatment goal. The clinical pharmacist intervention resulted in decreased HbA1c levels and improved glycemic control by enhancing patients’ knowledge and medication adherence over the one-year follow-up period.