Microbial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552

Bedir E., KULA C., Oner O., Altas M., Tag O., ÖNGEN ÖZGEN G.

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, cilt.115, ss.29-34, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 115
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.molcatb.2015.01.013
  • Dergi Adı: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.29-34
  • Anahtar Kelimeler: Astragalus, Microbial transformation, Cycloastragenol, Cyclocanthogenol, Astragenol, BIOTRANSFORMATION, ACID, CYCLOASTRAGENOL, TRITERPENOIDS
  • Marmara Üniversitesi Adresli: Evet

Özet

The microbial transformation of Astragalus sp. derived sapogenins, namely cycloastragenol, astragenol and cyclocanthogenol, by Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552 were investigated. The unique enzyme system of both fungi resulted hydroxylation, cyclization, dehydrogenation and oxidation reactions. Structures of the new metabolites were elucidated by 1-D (H-1, C-13, NOESY), 2-D NMR (DQF-COSY, HMBC, HMQC, NOESY) and HR-MS analyses. (C) 2015 Elsevier B.V. All rights reserved.