Diagnostic Modalities Based on Flow Cytometry for Chronic Granulomatous Disease: A Multicenter Study in a Well-Defined Cohort

Baris, HATİCE; Ogulur, Ismail; Akcam, Bengu; Kiykim, Ayca; Karagoz, Dilek; Saraymen, Berkay; Akgun, Gamze; Eltan, Sevgi; Aydemir, Sezin; Akidagi, Zeynep; Bentli, Esma; Nain, Ercan; Kasap, Nurhan; Baser, Dilek; Altintas, Derya; Camcioglu, Yildiz; Yesil, Gözde; Ozen, AHMET; Koker, Mustafa; Karakoc-Aydiner, ELİF; Baris, SAFA

doi:10.1016/j.jaip.2020.07.030

Diagnostic Modalities Based on Flow Cytometry for Chronic Granulomatous Disease: A Multicenter Study in a Well-Defined Cohort

Atıf İçin Kopyala

Baris H. E., Ogulur I., Akcam B., Kiykim A., Karagoz D., Saraymen B., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, cilt.8, sa.10, ss.3525-3535, 2020 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 8 Sayı: 10
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.jaip.2020.07.030
Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
Sayfa Sayıları: ss.3525-3535
Anahtar Kelimeler: Chronic granulomatous disease, NADPH oxidase, flow cytometry, Dihydrorhodamine, gp91, p22, p47, p67, MUTATIONS, DIHYDRORHODAMINE, OXIDASE, ASSAY, FAMILIES, CARRIERS, TURKEY, BURST
Marmara Üniversitesi Adresli: Evet

Özet

BACKGROUND: Chronic granulomatous disease (CGD) is characterized by defective microbial killing due to mutations affecting subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Definitive genetic identification of disease subtypes may be delayed or not readily available.