Atıf İçin Kopyala
Orak M. M., Ak D., Midi A., LAÇİN B., Purisa S., Bulut G.
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, cilt.49, sa.4, ss.438-446, 2015 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
49
Sayı:
4
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Basım Tarihi:
2015
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Doi Numarası:
10.3944/aott.2015.14.0312
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Dergi Adı:
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.438-446
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Anahtar Kelimeler:
Diclofenac, experimental study, intraarticular, methylprednisolone, tenoxicam, ANTIINFLAMMATORY DRUGS, ARTICULAR-CARTILAGE, STEROID INJECTIONS, DOUBLE-BLIND, OSTEOARTHRITIS, KNEE, ARTHROSCOPY, HYALURONATE, ANALGESIA, THERAPY
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Marmara Üniversitesi Adresli:
Evet
Özet
Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.