Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats


Orak M. M. , Ak D., Midi A., LAÇİN B. , Purisa S., Bulut G.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, cilt.49, sa.4, ss.438-446, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3944/aott.2015.14.0312
  • Dergi Adı: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Sayfa Sayıları: ss.438-446

Özet

Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.