The Importance of Stroma and Stromal SMA Expression in Pancreatic Ductal Adenocarcinoma.

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Akbas G., Bagci P.

Turk patoloji dergisi, 2024 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası:
  • Basım Tarihi: 2024
  • Doi Numarası: 10.5146/tjpath.2024.13521
  • Dergi Adı: Turk patoloji dergisi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Pancreatic stellate cells (PSC) have been defined to be the key players in pancreatic fibrogenesis and carcinogenesis. They undergo

myofibroblast-like differentiation, express α-smooth muscle actin (α-SMA), and play a crucial role in injury and inflammation sites. This study

aims to evaluate the relationship between α-SMA expression and histopathological parameters of pancreatic ductal adenocarcinoma (PDAC),

and investigate their association with prognosis.

Material and Methods: Eighty-one consecutive pancreatectomies diagnosed as usual pancreatic ductal adenocarcinoma were included. The

stromal density was scored as loose, moderate, or dense, and α-SMA expression was evaluated immunohistochemically.

Results and Conclusion: Mean survival was 19.6 months. Male gender, larger tumor diameter (>3.7 cm), and older age (>64 years) were

identified as independent poor prognostic factors. Perineural invasion significantly effected survival. A statistically significant correlation was

found between high α-SMA expression and the presence of angioinvasion (p=0.01). Stromal α-SMA expression in PDAC may help determine

the risk of angioinvasion.

Keywords: Pancreas, Cancer, Stellate cell, Tumor stroma, α-SMA, Angioinvasion