Potential Effect of 1,25 Dihydroxyvitamin D<sub>3</sub> on Thioacetamide-Induced Hepatotoxicity in Rats.

Özdemir-Kumral Z. N., Erkek B., Karakuş B., Almacı M., Fathi R., Yüksel M., ...Daha Fazla

The Journal of surgical research, cilt.243, ss.165-172, 2019 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 243
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jss.2019.05.020
  • Dergi Adı: The Journal of surgical research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.165-172
  • Anahtar Kelimeler: Apoptosis, 1,25(OH)(2)D-3, Hepatotoxicity, Oxidative stress, Rat, Thioacetamide, INDUCED LIVER-INJURY, VITAMIN-D, HEPATIC-ENCEPHALOPATHY, NITRIC-OXIDE, OXIDATIVE STRESS, APOPTOSIS, PROTECTS, INFLAMMATION, INVOLVEMENT, MODELS
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: 1,25 Dihydroxyvitamin D-3 (1,25(OH)(2)D-3) modulates inflammation and immune responses. Deficiency of 1,25(OH)(2)D-3 was found to be associated with the risk of cancer, cardiovascular disease, osteoarthritis, infections, and autoimmune diseases. This study evaluated the effect of 1,25 dihydroxyvitamin D-3 1,25(OH)(2)D-3 on thioacetamide (TAA)-induced acute liver injury in rats.