Akademik Veri Yönetim Sistemi
The 33rd World Congress on Controversies in Obstetrics, Gynecology & Infertility (COGI), Rome, İtalya, 27 - 29 Kasım 2025, ss.154, (Özet Bildiri)
Introduction: Gestational Diabetes Mellitus (GDM) is defined as any degree of glucose intolerance caused by physiologic changes that occur via placental factors during pregnancy. Risk factors for GDM include ethnicity, advanced maternal age, pre-pregnancy excessive weight or
obesity, family history of type 2 diabetes (T2D), polycystic ovarian syndrome (PCOS), multiple gestation, genetic factors, smoking, pre- pregnancy unhealthy diet, and sedentary lifestyle. It has been reported that cell dysfnction and insulin resistance (IR) play a role in etiopathogenesis of GDM. There are numerous studies regarding genetic susceptibility of GDM. SEPP1, rs13154178 (G/A); AHSG, rs4918 (C/G); HNF1A, rs1169288 (G/T); FTO, rs9939609 (T/A) polymorphisms are associated with GDM in the Turkish population in
previous studies. Also, the MTNR1B variants (rs10830963 and rs1387153) were associated with GDM. However, these variants have not been studied before in our population. The aim of this study was to investigate any relationship between these 6 SNPs and GDM. Methods: 78 pregnant women with GDM and 113 pregnant women with normal glucose tolerance were included in the study. Pregnant women with pregestational diabetes, thyroid disease, PCOS, hypertension, hyperlipidemia, and T2D were excluded. 75 gr oral glucose tolerance test (OGTT) at 24 to 28 week was performed for all participants. Samples were collected using buccal swabs, and genomic DNA was isolated from epithelial cells. Polymorphisms were detected using rhAmp SNP assay (IDT, USA) in real-time PCR (LightCycler 480, Roche Switzerland). Genotype and allele frequencies were compared between patient and control groups using Fisher`s exact test. Results: There was no significant difference between groups for rs4918, rs1169288, rs9939609, rs10830963 and rs1387153. A significantly higher frequency of genotypes carrying the A allele (GA and AA genotype) of SEPP1 rs13154178 (G/A) was observed in the control group (p=0.0081, OR: 0.44; 95% CI: 0.24-0.79). Conclusion: MTNR1B variants (rs10830963 and rs1387153) were not found to be associated with GDM risk in our study. However, this is the first study to examine the relationship between these SNPs and GDM in the Turkish population. Our results suggest that the presence of the A allele of SEPP1 rs13154178 (G/A) was significantly associated with a lower risk of GDM.