Triggering agents and microbiome as environmental factors on Behcet's syndrome
INTERNAL AND EMERGENCY MEDICINE, cilt.14, sa.5, ss.653-660, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 14 Sayı: 5
- Basım Tarihi: 2019
- Doi Numarası: 10.1007/s11739-018-2000-1
- Dergi Adı: INTERNAL AND EMERGENCY MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.653-660
- Anahtar Kelimeler: Triggering agents, Environmental factors, Microbiome, Behcet's syndrome, FAMILIAL MEDITERRANEAN FEVER, ORAL ULCER ACTIVITY, DAGGER-ETS DISEASE, CLINICAL-FEATURES, SALIVARY LEVELS, SKIN-LESIONS, HNP 1-3, NICOTINE, AUTOIMMUNITY, AZITHROMYCIN
- Marmara Üniversitesi Adresli: Evet
Özet
Environmental and other triggering factors are suggested to cause the onset and the clinical relapses of Behcet's syndrome (BS), a multi-systemic inflammatory disorder. In this review, environmental factors are discussed according to their interactions with etiopathogenesis, immune response and disease activity. Stress is a common self-triggering factor for most BS patients. Stimuli such as some foods can activate oral ulcers, and may be linked to the histamine content of the food. Oral/skin trauma and menstruation associated with hormonal factors aggravate, whereas allergy/atopy seem to alleviate the symptoms of BS. Infections are associated with BS, and microbial stimuli can activate inflammation in mucosal surfaces with increased Th1/Th17 responses. Fecal and oral microbiome patterns change in diversity and composition in BS. Better oral hygiene applications and anti-microbial interventions might be helpful to suppress oral ulcers in BS.