Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure

ŞENKARDEŞ S., TATAR E., Nepravishta R., Cela D., Paci M., Ozakpinar Ö., ...Daha Fazla

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.16, sa.9, ss.974-983, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 9
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570180815666180810120609
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.974-983
  • Anahtar Kelimeler: Acylhydrazones, anti-HIV activity, antileukemia activity, 2D-NMR spectroscopy, 3D structure, L-valine, microwave assisted synthesis, ACYLHYDRAZONE DERIVATIVES, ANTITUBERCULAR ACTIVITY, HCK INHIBITORS, CANCER, IDENTIFICATION, ANTICANCER, APOPTOSIS, REPLICATION
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Hydrazide-hydrazones constitute an important class of compounds for new drug development. In this study, a series of 39 new acylhydrazones (3-41), derived from (2S)-3-methyl-2-[[( 4-methylphenyl)sulfonyl]amino]butanoic acid hydrazide were synthesized with further aim to achieve biologically active acylhydrazones carrying an amino acid side chain.