Cardiac functions and aortic elasticity in children with inflammatory bowel disease: effect of age at disease onset

Erolu E., Polat E.

CARDIOLOGY IN THE YOUNG, cilt.30, sa.3, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1017/s1047951119002932
  • Dergi Adı: CARDIOLOGY IN THE YOUNG
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CINAHL, EMBASE, MEDLINE
  • Anahtar Kelimeler: Inflammatory bowel disease, myocardial functions, aortic elasticity, early-onset inflammatory bowel disease, late-onset inflammatory bowel disease, ULCERATIVE-COLITIS, ENDOTHELIAL DYSFUNCTION, ARTERIAL STIFFNESS, CROHNS-DISEASE, ACTIVITY INDEX, CLASSIFICATION, INVOLVEMENT, DIAGNOSIS, PROFILE, RISK
  • Marmara Üniversitesi Adresli: Hayır

Özet

Aim: Childhood onset inflammatory bowel disease is more aggressive and has rapidly progressive clinical course than adult inflammatory bowel disease. Early-onset inflammatory bowel disease has more severe clinical progression as a subspecialised group of monogenic inflammatory bowel disease. We studied cardiac functions and aortic elasticity in children with early- and late-onset inflammatory bowel disease in remission period. Methods: Thirty-three paediatric patients were divided into subgroups according to age of disease onset (<10 and >10 years of age). Twenty-five healthy children were admitted as control group. M-Mode echocardiography and pulsed wave Doppler echocardiography were performed. Strain, distensibility, stiffness index of ascending, and abdominal aorta were evaluated. Results: Interventricular septum (mm) and left ventricular end-systolic diameter were higher (6.9 +/- 1.2, 26.2 +/- 4.6) in early-onset inflammatory bowel disease patients than control patients (6.1 +/- 1.27, 22.7 +/- 4.12) (p = 0.050, p = 0.050). Mitral E/E' ratio and myocardial performance index were increased in inflammatory bowel disease and early-onset inflammatory bowel disease groups than control group (p = 0.046, p = 0.04; p = 0.023, p = 0.033). Diastolic functions were found to be impaired in inflammatory bowel disease and early-onset inflammatory bowel disease groups according to control group, while there was no difference between late-onset inflammatory bowel disease and control groups in terms of diastolic functions. Mitral E/A ratio was lower in inflammatory bowel disease patients and early-onset inflammatory bowel disease patients (1.46 +/- 0.32, 1.4 +/- 0.21) than control patients (1.70 +/- 0.27) (p = 0.013, p = 0.004). Aortic elasticity did not differ between groups. Conclusion: Chronic low-grade inflammation has effects on left ventricular diameters and diastolic function in remission period. Aortic elasticity is not affected in our study groups.