Serum prolidase, malondialdehyde and catalase levels for the evaluation of oxidative stress in patients with peripheral vertigo

Ozbay I., TOPUZ M. F., Oghan F., Kocak H., Kucur C.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, cilt.278, sa.10, ss.3773-3776, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 278 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00405-020-06466-x
  • Dergi Adı: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.3773-3776
  • Anahtar Kelimeler: Oxidative stress, Peripheral vertigo, Prolidase, Malondialdehyde, Catalase, NITRIC-OXIDE LEVELS
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring serum prolidase, malondialdehyde (MDA) and catalase levels. Methods A total of 30 patients (age: 60 <) with peripheral vertigo and 30 healthy subjects were recruited. Blood samples were collected from both groups and serum prolidase levels were measured using enzyme-linked immunosorbent assay (ELISA). MDA and catalase levels were measured by the spectrophotometric method. Results The most common cause of vertigo was BPPV (53.3%), followed by Meniere's disease (16.6%), vestibular neuritis (13.3%), lateral semicircular canal fistula (3.3%), and idiopathic vertigo (13.3%). Mean serum prolidase activity and MDA levels were significantly higher in the vertigo patients than in the control subjects (P < 0.05); however, there was no statistically significant difference in mean serum catalase levels between the groups (P > 0.05). Conclusion We concluded that serum prolidase and MDA levels may be used as markers of oxidative stress in patients with peripheral vertigo.