Does perioperative opioid infusion increase postoperative opioid requirement?


Senol Karatas S., Eti Z., Saracoglu K. T. , Gogus F. Y.

AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY, vol.27, no.1, pp.47-53, 2015 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.5505/agri.2015.71676
  • Title of Journal : AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY
  • Page Numbers: pp.47-53

Abstract

Objectives: Opioids are the cornerstone therapy for the optimal pain management. Perioperative opioid infusion is accused of causing acute opioid tolerance, especially as the postoperative opioid requirement increases in time to provide efficient analgesia. It is debatable whether there is a difference between opioid agents regarding tolerance development. We aim to compare the effects of morphine, remifentanil and alfentanil when infused intravenously during the perioperative period.