Does perioperative opioid infusion increase postoperative opioid requirement?

Senol Karatas S., Eti Z., Saracoglu K. T., Gogus F. Y.

AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY, cilt.27, sa.1, ss.47-53, 2015 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5505/agri.2015.71676
  • Dergi Adı: AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.47-53
  • Anahtar Kelimeler: Analgesia, continuous infusion, opioids, tolerance, MINIMUM ALVEOLAR CONCENTRATION, SMALL-DOSE KETAMINE, ACUTE TOLERANCE, SEVOFLURANE ANESTHESIA, REMIFENTANIL INFUSION, INDUCED HYPERALGESIA, ANALGESIC TOLERANCE, MORPHINE-TOLERANCE, RAPID DEVELOPMENT, RATS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives: Opioids are the cornerstone therapy for the optimal pain management. Perioperative opioid infusion is accused of causing acute opioid tolerance, especially as the postoperative opioid requirement increases in time to provide efficient analgesia. It is debatable whether there is a difference between opioid agents regarding tolerance development. We aim to compare the effects of morphine, remifentanil and alfentanil when infused intravenously during the perioperative period.