Synthesis, characterization and evaluation of antituberculosis activity of some hydrazones

Kaymakcioglu B., Rollas S.

FARMACO, cilt.57, sa.7, ss.595-599, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 7
  • Basım Tarihi: 2002
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.595-599
  • Anahtar Kelimeler: 4-amino-3,5-di/1,3,5-trimethylpyrazoles, hydrazones, antituberculosis activity, DERIVATIVES
  • Marmara Üniversitesi Adresli: Hayır

Özet

Several new hydrazone derivatives were prepared by the reaction of some active hydrogen compounds with the diazonium salts of 4-amino-3,5-di/1,3,5-trimethylpyrazoles at 0-5 degreesC. Structures of the new substances were confirmed using UV, IR, H-1 NMR, C-13 NMR and EI-mass spectral data. In vitro antituberculosis activity of these compounds were tested on Mycobacterium tuberculosis H37Rv at 6.25 mug/ml. Both hydrazone products, ethyl 2-[(3,5-dimethylpyrazole-4-yl)hydrazono]-3-oxobutyrate (3d) and methyl 2-[(3,5-dimethylpyrazole-4-yl)hydrazono]-4-methoxy-3-oxobutyrate (3e) showed 29 and. 28% inhibition against M. tuberculosis, respectively. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.