Effect of antithrombin-III (AT-III) on morphological changes in small intestine in experimental obstructive jaundice model

Caglikulekci M., Dirlik M., Scatton O., Cinel I., Ozer I., Cinel L., ...More

ANNALES DE CHIRURGIE, vol.129, no.5, pp.273-277, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 129 Issue: 5
  • Publication Date: 2004
  • Doi Number: 10.1016/j.anchir.2004.01.008
  • Journal Name: ANNALES DE CHIRURGIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.273-277
  • Marmara University Affiliated: No

Abstract

Purpose. - Bacterial translocation leading to sepsis is increased by obstructive jaundice(OJ). Antithrombin III (ATIII) mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. We investigated the effect of ATIII on histopatology and villus morphology of small intestine.