There are no estrogen and progesterone receptors in cerebral cavernomas A preliminary immunohistochemical study

KAYA A. H., ULUS A., BAYRİ Y., TOPAL A., GÜN S., KANDEMİR B., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.72, sa.3, ss.263-265, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.surneu.2008.09.014
  • Dergi Adı: SURGICAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.263-265
  • Anahtar Kelimeler: Cavernoma, Bleeding, Estrogen, Progesterone, Seizure, BRAIN-STEM, STRUCTURAL PROTEINS, ANGIOGENIC FACTORS, NATURAL-HISTORY, EXPRESSION, HEMANGIOMA, MALFORMATIONS, ANGIOMAS, GROWTH
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Literature consistently mentions that pregnancy and hormonal therapy probably increase the bleeding rate and seizure expression of cerebral cavernomas. Either increased hormonal activity or embryogenesis related abundant expression of some growth factors such as VEGF, bFGF, and placental growth factor during pregnancy were proposed to initiate angiogenic process and vascular proliferation in cavernomas, thereby increasing their bleeding rate and seizure expression.