Atıf İçin Kopyala
Kantarcioglu B., Kaygusuz-Atagunduz I., Uzay A., TOPTAŞ T., Tuglular T. F., Bayik M.
INTERNATIONAL JOURNAL OF HEMATOLOGY, cilt.102, sa.3, ss.383-387, 2015 (SCI-Expanded)
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Yayın Türü:
Makale / Derleme
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Cilt numarası:
102
Sayı:
3
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Basım Tarihi:
2015
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Doi Numarası:
10.1007/s12185-015-1792-2
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Dergi Adı:
INTERNATIONAL JOURNAL OF HEMATOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.383-387
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Anahtar Kelimeler:
t(9;22), Myelodysplastic syndrome, BCR-JAK2, Fusion gene, JAK2 rearrangement, CHRONIC EOSINOPHILIC LEUKEMIA, ACUTE LYMPHOBLASTIC-LEUKEMIA, CHRONIC MYELOID-LEUKEMIA, JAK2, TRANSLOCATION, PATIENT, GENE, RUXOLITINIB, REARRANGEMENTS, DISORDERS
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Marmara Üniversitesi Adresli:
Evet
Özet
The human JAK2 gene is mainly targeted by two types of genetic lesions that play roles in the pathogenesis of hematologic malignancies: intragenic mutations and chromosomal translocations. Chromosomal translocations of JAK2 are typically associated with myeloid or lymphoid malignancies with an aggressive course and poor outcome. Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature.