Breast lesions with myoepithelial phenotype

Foschini M. P., Nishimura R., Fabbri V. P., Varga Z., KAYA H., Cserni G.

Histopathology, cilt.82, sa.1, ss.53-69, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 82 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1111/his.14826
  • Dergi Adı: Histopathology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.53-69
  • Anahtar Kelimeler: myoepithelial cell, breast, epithelial cell, myoepitheliosis, myoepithelial cell differentiation, ADENOID-CYSTIC CARCINOMA, GRADE ADENOSQUAMOUS CARCINOMA, COLLAGENOUS SPHERULOSIS, PLEOMORPHIC ADENOMA, LOBULAR CARCINOMA, DUCTAL CARCINOMA, SOLID VARIANT, IN-SITU, CLINICOPATHOLOGICAL CHARACTERISTICS, MALIGNANT ADENOMYOEPITHELIOMA
  • Marmara Üniversitesi Adresli: Evet

Özet

© 2022 John Wiley & Sons Ltd.Myoepithelial cells (MECs) constitute a continuous layer of cells surrounding the breast glands, localised between the epithelial cells (ECs) and the basal membrane. MECs play important roles in normal mammary gland as they produce basal membrane and stimulate secretion. During neoplastic transformation, MECs act as a barrier preventing stromal invasion. MECs themselves can undergo a great variety of changes, ranging from hyperplastic to metaplastic, to neoplastic, and giving rise to a wide spectrum of morphological pictures sometimes difficult to interpret on routine diagnoses. Several benign and malignant breast tumours can present features of MECs differentiation. As these latter tumours are quite infrequent, the purpose of the present study is to offer a review of the morphological spectrum of MECs lesions, with correlations to prognosis.