Akademik Veri Yönetim Sistemi
Diabetology & Metabolic Syndrome, cilt.18, sa.87, ss.1-20, 2026 (SCI-Expanded)
Abstract
Background The aim of the study is to evaluate the effects of 12-week high-intensity interval training (HIIT) on
body composition, metabolic hormones, insulin resistance, lipid profile, inflammation, and oxidative stress markers in
adolescents with obesity.
Methods Thirty-two (female
=
19; male
=
13) adolescent volunteers with obesity were divided into two groups:
training and control. Participants underwent health checks with resting electrocardiogram (ECG) and blood pressure
monitoring. Anthropometric measurements, body composition components, and biochemical tests were performed
in pre and post-tests of all participants. Serum fasting glucose, insulin, total cholesterol, triglyceride, high and
low-density lipoproteins, leptin, adiponectin, High-Sensitivity C-Reactive Protein (hs-CRP), Tumor Necrosis Factor-
alpha (TNF-α), Interleukin-6 (IL-6), hs-CRP, TNF-alpha, IL-6, prooxidant, and antioxidant parameters were analyzed
biochemically. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated. The training group
participated in a HIIT program for 12 weeks, 3 days a week, for a total of 36 sessions, after 3 weeks of pre-adaptation
studies. Heart rate was monitored with a heart rate monitor. The control group was not included in any exercise
program during this period.
Results The mean age of the adolescents with obesity included in the study was 15.28 ± 2.93 years and Body Mass
Index (BMI) was 33.21 ± 4.98 kg/m2. Group, sex, and time interaction effects showed that HOMA-IR and triglyceride
levels had reduced in the HIIT group (p < 0.001). The group-time interaction effect was observed in the parameters
related to body composition, metabolism, inflammation, and pro-oxidant status (p < 0.05). BMI, waist and hip
circumferences, body fat (%), insulin, glucose, total cholesterol, LDL, triglyceride, and leptin were decreased in the HIIT
group (p < 0.05). While lean mass, muscle mass, body water and adiponectin were increased in the HIIT intervention
group (p < 0.05). The inflammation parameters (hs-CRP, TNF-α, and IL-6), and pro-oxidant indicator Advanced Glycation
End Products (AGEs) were decreased in the HIIT group.