Salivary levels of antimicrobial peptides Hnp 1-3, Ll-37 and S100 in Behcet's disease.

MUMCU G., Cimilli H., Karacayli U., Inanc N., Ture-Ozdemir F., Eksioglu-Demiralp E., ...More

Archives of oral biology, vol.57, no.6, pp.642-6, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1016/j.archoralbio.2011.11.003
  • Journal Name: Archives of oral biology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.642-6
  • Keywords: Behget disease, Saliva and HNP 1-3, EXPRESSION, NEUTROPHILS, CARIES, CELLS, PATHOGENESIS, ASSOCIATION, ACTIVATION, SEVERITY, PROTEINS, HEALTH
  • Marmara University Affiliated: Yes

Abstract

Background: Oral ulcer is the cardinal clinical sign and increased neutrophilic activity is a part of the pathogenesis in Behcet's disease (BD). Saliva, as a part of the innate immune response, contains antimicrobial peptides (AMPs) that are derived from both oral epithelial cells and neutrophils. The aim of this study was to investigate the associations between salivary levels of AMPs HNP 1-3, LL-37 and S100 and disease course in patients with Behcet's disease (BD).