Akademik Veri Yönetim Sistemi
British Journal of Urology, cilt.80, sa.SUPPL. 2, ss.249, 1997 (SCI-Expanded, Scopus)
We aimed to compare preoperative tumor localization by transrectal ultrasonography (TRUS) and TRUS guided core biopsies with the final histopathological examination of radical prostatectomy specimens. Forty-eight patients who underwent radical retropubic prostatectomy after evaluation with TRUS are included into the study. Diagnosis of prostate cancer (PCa) was established with TRUS guided systematic (3 cores from base, mid and apex of the peripheral zone, and 1 core from transitional zone of each side of the prostate) and lesion directed core biopsies in all cases. Histopathological examination of the prostatectomy specimens revealed PCa bilaterally in 43 glands and unilaterally in five gland. Preprostatectomy TRUS examinations revealed 53 hypoechoic lesions and additional 384 random biopsies (48x8) were obtained from normal appearing prostate segments. Fifty-one of the 53 hypoechoic lesions were proved to have adenocarcinoma on histopathological examination of lesion directed core biopsies (96%). In prostate regions with normal TRUS findings, a total of 261 areas were found to have adenocarcinoma on final pathology. Systematic biopsies revealed only 98 of these lesions (98/261= 37.5%). In the remaining 286 random biopsy, there were 163 areas which were proved to be adenocarcinoma on final pathology. This study reveals that 80% of all PCa lesions (210/261) could not be recognized by TRUS and 46.6% of them could be diagnosed by additional systematic biopsies. Furthermore, even with TRUS guided systematic core biopsies failure to detect the PCa lesions may be as high as 62.4% (163/261).