Protein Expression in the Diagnosis of LRBA Deficiency by Flow Cytometer


ÖĞÜLÜR İ. , Kiykim A., Nain E., Somer A., Guven A., BARIŞ S. , ...Daha Fazla

ASTIM ALLERJI IMMUNOLOJI, cilt.15, sa.3, ss.123-128, 2017 (ESCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.21911/aai.368
  • Dergi Adı: ASTIM ALLERJI IMMUNOLOJI
  • Sayfa Sayıları: ss.123-128

Özet

Objective: Lipopolysaccharide-responsive beige-like anchor (LRBA) plays a role in cell surface expression of inhibitory cytotoxic T lymphocyte-associated protein-4 (CTLA-4) protein. Recently identified LRBA deficiency leads to immune deficiency and autoimmunity and is diagnosed by mutation analyses and protein expression. Herein, we quantified stimulated and unstimulated intracellular LRBA protein expression by flow cytometry in LRBA deficiency patients.