Ghrelin against alendronate-induced gastric damage in rats

Iseri S., Sener G., Yuksel M., Contuk G., Cetinel S., Gedik N., ...Daha Fazla

JOURNAL OF ENDOCRINOLOGY, cilt.187, sa.3, ss.399-406, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 187 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1677/joe.1.06432
  • Dergi Adı: JOURNAL OF ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.399-406
  • Marmara Üniversitesi Adresli: Evet

Özet

Alendronate sodium, a primary amino bisphosphonate, is widely used in the treatment of various diseases that are associated with bone resorption, such as postmenopausal osteoporosis and Paget's disease of bone. Although the adverse effects of biphosphonates on the gastrointestinal system have been demonstrated in experimental and clinical studies, the exact mechanisms underlying this damage are not clear yet. Ghrelin, a 28 amino acid peptide produced predominantly by the stomach, was shown to exert a potent protective action on the stomach of rats exposed to ethanol or stress.