Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring


Schoell I., Ackermann U., Ozdemir C., Bluemer N., Dicke T., Sel S., ...Daha Fazla

FASEB JOURNAL, cilt.21, sa.4, ss.1264-1270, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Konu: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1096/fj.06-7223com
  • Dergi Adı: FASEB JOURNAL
  • Sayfa Sayıları: ss.1264-1270

Özet

The treatment of dyspeptic disorders with anti-acids leads to an increased risk of sensitization against food allergens. As these drugs are taken by 30-50% of pregnant women due to reflux and heartburn, we aimed here to investigate the impact of maternal therapy with anti-acids on the immune response in the offspring in a murine model. Codfish extract as model allergen was fed with or without sucralfate, an anti-acid drug, to pregnant BALB/c mice during pregnancy and lactation. These mothers developed a codfish-specific allergic response shown as high IgG1 and IgE antibody levels and positive skin tests. In the next step we analyzed whether this maternal sensitization impacts a subsequent sensitization in the offspring. Indeed, in stimulated splenocytes of these offspring we found a relative Th2-dominance, because the Th1- and T-regulatory cytokines were significantly suppressed. Our data provide evidence that the anti-acid drug sucralfate supports sensitization against food in pregnant mice and favors a Th2-milieu in their offspring. From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants.